58. Turning Science into Aid: The Fight Against Neglected Global Diseases w/ Dr. Kishor Wasan
This episode is proudly supported by the Neglected Global Disease Initiative at the University of British Columbia
Dr. Kishor Wasan, a dedicated academic at the University of British Columbia (UBC), has committed his career to tackling neglected global diseases and broadening access to essential medicines. In an interview, Dr. Wasan opens up about his unexpected journey, the challenges faced, and the significant achievements of the Neglected Global Diseases Initiative (NGDI) at UBC.
An Unexpected Turn
Dr. Kishor Wasan’s career in pharmaceutical sciences began traditionally, with a focus on corporate collaborations and lucrative research. However, his path took an unexpected turn during a presentation on antifungal therapies at Vancouver General Hospital. A thought-provoking challenge from a physician to develop an oral formulation of Amphotericin B—a drug confined to intravenous use due to significant toxicities—sparked a new direction in his professional journey.
“I never imagined that a simple question during a hospital presentation could so radically shift my focus,” Dr. Wasan recalls. “It was a challenge thatI, and my students, initially thought was impossible. Yet, it became the catalyst for something much greater.”
The Genesis of NGDI
Dr. Wasan’s journey into the realm of neglected diseases further unfolded with an inquisitive question from Andrew, a first-year medical student. Andrew suggested that the newly developed oral Amphotericin B could be employed to treat leishmaniasis, a devastating parasitic disease rampant in low and middle-income countries (LMICs).
Reflecting on this turning point, Dr. Wasan notes, “When Andrew approached me about using our formulation for leishmaniasis, my initial reaction was, ‘What the heck is leishmaniasis?’ But that curiosity led to a deeper understanding of the vast unmet needs in global health.”
Motivated by the potential humanitarian impact, Dr. Wasan and his team embarkedon the development of a cost-effective, safe, and stable oral formulation of Amphotericin B. This work served as the cornerstone for the establishment of the NGDI at UBC. Alongside Dr. Bob Hancock, a prominent microbiologist, NGDI was co-founded with the mission to mobilize researchers focused on neglected diseases and create meaningful partnerships to improve global health access.
Navigating Immense Challenges
Raising awareness and securing funding for neglected diseases proved to be major hurdles. These diseases, often affecting impoverished populations in remote regions, have historically lacked the attention and resources necessary for effective treatment. However, the landscape is evolving.
“Social media and increasing awareness due to climate change have been game-changers,” says Dr. Wasan. “Funders like the Bill and Melinda Gates Foundation and the Drugs for Neglected Diseases initiative are also making a profound difference.”
Achievements and Breakthroughs
NGDI’s successes are significant and varied. Among the notable achievements is the advancement of the oral Amphotericin B program, now approaching phase two clinical trials. Other impactful projects include Dr. Richard Lester’s Welltel initiative, which utilizes telemedicine to improve drug adherence in Rwanda, and Dr. Katherine Hughes’ research on malaria in renal dysfunction patients in Africa.
“Oral Amphotericin B is a landmark project for us,” Dr. Wasan explains. "It's gratifying to finally see it nearing clinical implementation."
A Distinctive Approach
NGDI’s unique approach is rooted in the global access and equity principles established by UBC in 2007. These principles ensure that technologies developed for LMICs are provided at or below cost, prioritizing humanitarian goals over commercial interests.
“Our commitment is reflected in every project we undertake,” Dr. Wasan emphasizes. “It’s about ensuring that our discoveries reach those who need them most, without the barrier of cost.”
Guidance for Future Advocates
Dr. Kishor Wasan
Dr. Wasan also offers insightful advice for students and young researchers eager to contribute to global health. “My advice to students is to find your specific niche within the vast field of global health and connect with relevant organizations,” he advises. “There are so many opportunities now to get involved, network, and contribute meaningfully. Take advantage of these resources.”Emphasizing the role of mentorship and networking, Dr. Wasan adds, “Seek guidance from professors and professionals. They can help connect you with the right people to further your interests and make an impact.”
Conclusion: The Road Ahead
Dr. Wasan's passion and dedication, along with the NGDI's impactful work, are paving the way for significant advancements in global health. The initiative continues to strive towards its mission, with exciting prospects on the horizon.“We’re close to seeing real-world applications of our discoveries,” Dr. Wasan concludes. “It’s about making a lasting difference in people's lives, one breakthrough at a time.”Through perseverance, collaboration, and a steadfast commitment to equity, NGDI is not just transforming global health; it is setting a new standard for how research can directly impact the world's most vulnerable populations.
Dr. Kishor M. Wasan is a Canadian pharmacologist, pharmacist and professor. He was the dean of the University of Saskatchewan's College of Pharmacy and Nutrition from 2014 to 2019 and associate dean of research and graduate studies at the Faculty of Pharmaceutical Sciences at the University of British Columbia (UBC) from 2011 to 2014. Previously at UBC, he was chair of pharmaceutics and national director of the Canadian Summer Student Research Program after first joining the faculty in 1995. Wasan's research focuses on lipid-based drug delivery and the interaction between lipoprotein and pharmaceuticals. He has published more than 550 peer-reviewed articles and abstracts. He has a Public Leadership Credential from Harvard Kennedy School 2021. He is a founding member and currently co-director of UBC's Neglected Global Diseases Initiative and an adjunct professor in the Department of Urologic Sciences in the Faculty of Medicine at UBC. Dr. Wasan has received numerous awards (over 25) for his contributions to health sciences and is currently a fellow of CAHS, CSPS and AAPS, a fellow member of the Royal Society of Medicine (London, UK) and a member of the Sigma Xi Scientific Research Honour Society.
